Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13713493 | 0.82 | OPRM1 (0.43) | P2RX7GRM5RAB9AMEN1KMT2A | |
| SCHEMBL21993660 | 0.79 | TP53 (0.39) | P2RX7GRM5RAB9AMEN1KMT2A | |
| SCHEMBL13713005 | 0.79 | RAB9A (0.40) | P2RX7GRM5RAB9AMEN1KMT2A | |
| SCHEMBL24864136 | 0.78 | SMN1; SMN2 (0.41) | P2RX7GRM5RAB9AMEN1KMT2A | |
| SCHEMBL20909909 | 0.76 | RAB9A (0.43) | P2RX7GRM5RAB9AMEN1KMT2A | |
| SCHEMBL15174120 | 0.76 | RAB9A (0.43) | P2RX7GRM5RAB9AMEN1KMT2A | |
| SCHEMBL852406 | 0.75 | PAX8 (0.42) | P2RX7GRM5RAB9AMEN1KMT2A | |
| SCHEMBL9665431 | 0.75 | RAB9A (0.42) | P2RX7GRM5RAB9AMEN1KMT2A | |
| SCHEMBL13606319 | 0.74 | GRM5 (0.42) | P2RX7GRM5RAB9ACCR1CCR8 | |
| SCHEMBL6482424 | 0.72 | RAB9A (0.40) | P2RX7GRM5RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007141473-A1 | N-(BENZOYL)-O- [2- (PYRIDIN- 2 -YLAMINO) ETHYL] -L-TYROSINE DERIVATIVES AND RELATED COMPOUNDS AS A5B1 ANTAGONISTS FOR THE TREATMENT OF SOLID TUMORS | ASTRAZENECA AB (SE) | 2007-12-13 | — | — | WO | disclosed |