SCHEMBL24865645

SCHEMBL24865645

Cc1c(Nc2ccc(N(C)C)c(OCC=O)c2)ccc(N2CCC(C(F)(F)F)CC2)c1F

nearest known ligand 0.34

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
FGFR3 P22607 8/20 0.34
ADRA1D P25100 1/20 0.32
ADRA1A P35348 1/20 0.32
ADRA1B P35368 1/20 0.32
KCNH2 Q12809 2/20 0.32
TRPV1 Q8NER1 1/20 0.32
FGFR1 P11362 1/20 0.32
FGFR2 P21802 1/20 0.32
FGFR4 P22455 1/20 0.32
KDR P35968 1/20 0.32
BCL6 P41182 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24865437 0.83 BCL6 (0.38) FGFR3KCNH2BCL6
SCHEMBL24865335 0.80 KIT (0.35) FGFR3KCNH2TRPV1BCL6
SCHEMBL24865667 0.77 ALK (0.33) BCL6
SCHEMBL24865707 0.77 JAK2 (0.32) BCL6
SCHEMBL24865215 0.73 PTK2 (0.33) BCL6
SCHEMBL24865544 0.73 BCL6 (0.35) BCL6
Hydrochloric Acid SCHEMBL25188782 0.72 TRPV1 (0.33) TRPV1
SCHEMBL24864955 0.71 KDM4E (0.36) BCL6
SCHEMBL24865751 0.71 FGFR3 (0.39) FGFR3KCNH2FGFR1FGFR2FGFR4
SCHEMBL24865761 0.70 JAK2 (0.33) BCL6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023280296-A1 FERROPTOSIS MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd. (KY) 2023-01-12 WO disclosed