Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867297 | 0.82 | PTGS1 (0.45) | PTGS1PTGS2RAB9AACACBMAPK1 | |
| SCHEMBL24866872 | 0.81 | PTGS1 (0.45) | PTGS1PTGS2ACACB | |
| SCHEMBL24867298 | 0.81 | PTGS1 (0.38) | PTGS1PTGS2TGFBR1RAB9AMAPK1 | |
| SCHEMBL24867304 | 0.81 | RAB9A (0.40) | PTGS1PTGS2TGFBR1RAB9AMAPK1 | |
| SCHEMBL24867299 | 0.81 | PDE4A (0.39) | ACACB | |
| SCHEMBL24867214 | 0.80 | RAB9A (0.43) | PTGS1PTGS2TGFBR1RAB9AACACB | |
| SCHEMBL24867489 | 0.80 | CDK2 (0.38) | RAB9AACACBTBK1MAPK1 | |
| SCHEMBL24867301 | 0.80 | PDE4A (0.38) | ACACB | |
| SCHEMBL24867187 | 0.79 | ACACB (0.38) | PTGS1PTGS2TP53RAB9AACACB | |
| SCHEMBL24866865 | 0.78 | CDK1 (0.39) | PTGS1PTGS2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |