Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | CTSC | P53634 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.36 |
| ▸ | CFD | P00746 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867228 | 0.90 | AKT1 (0.46) | AKT1RAB9AMETCTSCCDK5 | |
| SCHEMBL24866902 | 0.88 | HDAC3 (0.46) | HDAC3HDAC1HDAC2HDAC6RAB9A | |
| SCHEMBL24867231 | 0.86 | CFD (0.39) | AKT1IDO1HDAC3HDAC1HDAC2 | |
| SCHEMBL24867225 | 0.85 | PTGS1 (0.43) | IDO1METPTGS1CDK5CDK5R1 | |
| SCHEMBL24867214 | 0.85 | RAB9A (0.43) | AKT1RAB9APTGS1PTGS2KCNH3 | |
| SCHEMBL24867233 | 0.84 | CDK2 (0.43) | CDK5CDK5R1SYKKCNH3P2RX3 | |
| SCHEMBL24867232 | 0.84 | AKT1 (0.37) | AKT1IDO1HDAC3HDAC1HDAC2 | |
| SCHEMBL24866903 | 0.84 | CDK5 (0.40) | CDK5CDK5R1SYKP2RX3 | |
| SCHEMBL24867248 | 0.83 | IDH2 (0.47) | PTGS1SYK | |
| SCHEMBL24866885 | 0.79 | RAB9A (0.52) | AKT1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |