Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | TDO2 | P48775 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 5/20 | 0.35 |
| ▸ | FLT1 | P17948 | 2/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867214 | 0.84 | RAB9A (0.43) | AKT1PTGS1CDK4CCND1CCND2 | |
| SCHEMBL24866909 | 0.84 | AKT1 (0.42) | AKT1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL24866862 | 0.76 | HDAC3 (0.48) | HDAC3HDAC1HDAC2HDAC6KDR | |
| SCHEMBL24867244 | 0.75 | RAB9A (0.44) | HDAC3HDAC1HDAC2HDAC6CDK2 | |
| SCHEMBL24866902 | 0.74 | HDAC3 (0.46) | HDAC3HDAC1HDAC2HDAC6KDR | |
| SCHEMBL24867228 | 0.73 | AKT1 (0.46) | AKT1KDRRAB9ASYK | |
| SCHEMBL24867148 | 0.73 | RAB9A (0.40) | FLT4PTGS1CDK2RAB9ACCNA2 | |
| SCHEMBL24866885 | 0.73 | RAB9A (0.52) | AKT1CDK2CCND3RAB9ACCNA2 | |
| SCHEMBL30130169 | 0.73 | RAB9A (0.52) | AKT1CDK2CCND3RAB9ACCNA2 | |
| SCHEMBL24867179 | 0.72 | MAPK1 (0.37) | AKT1HDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |