Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 3/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.33 |
| ▸ | ULK1 | O75385 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 2/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867264 | 1.00 | AOC3 (0.36) | AOC3LRRK2PIM1CDK7CDK9 | |
| SCHEMBL24867267 | 0.87 | DYRK1A (0.41) | AOC3MAPK1ULK1MAPK8MAPK9 | |
| SCHEMBL24866919 | 0.85 | FLT3 (0.38) | AOC3LRRK2PIM1MAPK1DEGS1 | |
| SCHEMBL24867263 | 0.80 | MAPK1 (0.56) | AOC3MAPK1MAPK8MAPK9 | |
| SCHEMBL24866922 | 0.79 | MAPK1 (0.36) | AOC3MAPK1ULK1PTGS1 | |
| SCHEMBL24866931 | 0.79 | AOC3 (0.38) | AOC3MAPK1ULK1MAPK8MAPK9 | |
| SCHEMBL24867261 | 0.79 | MAP4K1 (0.42) | AOC3 | |
| SCHEMBL24867265 | 0.79 | ROCK2 (0.53) | AOC3DYRK1A | |
| SCHEMBL24867275 | 0.71 | MAPK8 (0.41) | MAPK8MAPK9DYRK1A | |
| SCHEMBL24866850 | 0.68 | MAP4K1 (0.45) | SYKBTKPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |