Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 11/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
| ▸ | ULK1 | O75385 | 1/20 | 0.35 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867264 | 0.87 | AOC3 (0.36) | DYRK1AMAPK8MAPK9AOC3ULK1 | |
| SCHEMBL24867273 | 0.87 | AOC3 (0.36) | DYRK1AMAPK8MAPK9AOC3ULK1 | |
| SCHEMBL24867275 | 0.84 | MAPK8 (0.41) | DYRK1AMAPK3RETMAPK8MAPK9 | |
| SCHEMBL24867263 | 0.83 | MAPK1 (0.56) | MAPK3MAPK8MAPK9MKNK1AOC3 | |
| SCHEMBL24866922 | 0.82 | MAPK1 (0.36) | MAPK3AOC3ULK1MAPK1 | |
| SCHEMBL24867261 | 0.82 | MAP4K1 (0.42) | RETAOC3 | |
| SCHEMBL24866931 | 0.82 | AOC3 (0.38) | MAPK3MAPK8MAPK9AOC3GBA1 | |
| SCHEMBL24867265 | 0.77 | ROCK2 (0.53) | DYRK1AAOC3 | |
| SCHEMBL28314223 | 0.71 | KDM4E (0.58) | RETMAPK8MAPK9MKNK1MKNK2 | |
| SCHEMBL24866919 | 0.71 | FLT3 (0.38) | MAPK8MAPK9AOC3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |