SCHEMBL2486780

SCHEMBL2486780

CC1(C)OB(c2cc(F)c(C(F)(F)Oc3ccc(-c4cc(F)c(C(F)(F)F)c(F)c4)c(F)c3)c(F)c2)OC1(C)C

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
LPL P06858 3/20 0.35
LIPG Q9Y5X9 3/20 0.35
ALOX5AP P20292 1/20 0.33
FEN1 P39748 1/20 0.33
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA9 Q16790 1/20 0.32
GRM2 Q14416 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9913189 0.93 LPL (0.35) LPLLIPGALOX5APFEN1CA1
SCHEMBL12357206 0.90 LPL (0.36) LPLLIPGALOX5APFEN1CA1
SCHEMBL2393633 0.87 LPL (0.36) LPLLIPGCA1CA2CA9
SCHEMBL12760441 0.87 LPL (0.37) LPLLIPGCA1CA2CA9
SCHEMBL12357207 0.85 LPL (0.39) LPLLIPGALOX5APFEN1CA1
SCHEMBL13218909 0.80 LPL (0.36) LPLLIPGCA1CA2CA9
SCHEMBL9913718 0.79 ALOX5AP (0.30) ALOX5APFEN1
SCHEMBL12226114 0.78 GPR3 (0.40) ALOX5APFEN1GRM2
SCHEMBL587211 0.78 LPL (0.44) LPLLIPGCA1CA2CA9
SCHEMBL14235285 0.77 ALOX5AP (0.39) ALOX5APFEN1GRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8551359-B2 Liquid-crystalline compounds and liquid-crystalline media MERCK PATENT GMBH (DE) 2013-10-08 US disclosed
US-8551359-B2 Liquid-crystalline compounds and liquid-crystalline media MERCK PATENT GMBH (DE) 2013-10-08 US disclosed
US-8551359-B2 Liquid-crystalline compounds and liquid-crystalline media MERCK PATENT GMBH (DE) 2013-10-08 US disclosed
EP-2377909-B1 Liquid crystalline compounds and liquid crystalline media MERCK PATENT GMBH (DE) 2013-01-23 EP disclosed
EP-2377909-B1 Liquid crystalline compounds and liquid crystalline media MERCK PATENT GMBH (DE) 2013-01-23 EP disclosed
US-20110253935-A1 LIQUID-CRYSTALLINE COMPOUNDS AND LIQUID-CRYSTALLINE MEDIA Merck Patent Gesellschaft mit bescrankter Haftung (DE) 2011-10-20 US disclosed
US-20110253935-A1 LIQUID-CRYSTALLINE COMPOUNDS AND LIQUID-CRYSTALLINE MEDIA Merck Patent Gesellschaft mit bescrankter Haftung (DE) 2011-10-20 US disclosed
US-20110253935-A1 LIQUID-CRYSTALLINE COMPOUNDS AND LIQUID-CRYSTALLINE MEDIA Merck Patent Gesellschaft mit bescrankter Haftung (DE) 2011-10-20 US disclosed
EP-2377909-A1 Liquid crystalline compounds and liquid crystalline media Merck Patent GmbH (DE) 2011-10-19 EP disclosed
EP-2377909-A1 Liquid crystalline compounds and liquid crystalline media Merck Patent GmbH (DE) 2011-10-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110253935-A1 LIQUID-CRYSTALLINE COMPOUNDS AND LIQUID-CRYSTALLINE MEDIA CFB, CFD, LCT LPL 105/4885LIPG 711/4885ALOX5AP 1014/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.