Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23290796 | 0.73 | ALDH1A1 (0.49) | KDM4EHSD17B10ADORA2AALDH1A1 | |
| SCHEMBL2171161 | 0.72 | DHFR (0.44) | KDM4EL3MBTL1HSD17B10MAT2APTGS2 | |
| Hydrochloric Acid SCHEMBL23291097 | 0.71 | ALDH1A1 (0.47) | KDM4EHSD17B10ADORA2AALDH1A1 | |
| SCHEMBL29414078 | 0.70 | MAPK1 (0.40) | KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL1499196 | 0.69 | RBP4 (0.40) | HSD17B10TGFBR1PTGS2 | |
| SCHEMBL2174181 | 0.68 | PDE4B (0.33) | KDM4EALDH1A1 | |
| SCHEMBL31601912 | 0.65 | SMPD3 (0.59) | KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL13050645 | 0.64 | SCN5A (0.35) | — | |
| SCHEMBL13050635 | 0.63 | CCR4 (0.33) | KDM4EL3MBTL1HSD17B10ALDH1A1 | |
| SCHEMBL4761878 | 0.62 | HTT (0.47) | KDM4EL3MBTL1HSD17B10MAT2APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379552-A1 | SUBSTITUTED BICYCLIC IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | Ortho-McNeil-Janssen Pharmaceuticals, Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010070008-A1 | SUBSTITUTED BICYCLIC IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2010-06-24 | — | — | WO | disclosed |