Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 6/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | LPL | P06858 | 2/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3781706 | 0.77 | CA2 (0.41) | ENPP2CA2CA1LPLLIPG | |
| SCHEMBL8342155 | 0.75 | GAA (0.37) | — | |
| SCHEMBL14951276 | 0.73 | HIF1A (0.43) | ENPP2CA2CA1LPLLIPG | |
| SCHEMBL3783983 | 0.72 | ENPP2 (0.41) | ENPP2CA2CA1LPLLIPG | |
| SCHEMBL12327206 | 0.71 | TTR (0.42) | ENPP2CA2CA1LPLLIPG | |
| SCHEMBL14951292 | 0.69 | APP (0.40) | ENPP2CA2CA1LPLLIPG | |
| SCHEMBL22912203 | 0.69 | TRPA1 (0.35) | — | |
| SCHEMBL3781842 | 0.68 | PRKCI (0.50) | ENPP2CA2CA1LPLLIPG | |
| SCHEMBL12327211 | 0.68 | TTR (0.38) | ENPP2CA2CA1LPLLIPG | |
| SCHEMBL14476938 | 0.68 | KIF11 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023280283-A1 | COMPOUND USED AS SHP2 INHIBITOR AND USE THEREOF | 浙江同源康医药股份有限公司 | 2023-01-12 | — | — | WO | disclosed |