Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 8/20 | 0.51 |
| ▸ | CTRC | Q99895 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RARA | P10276 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28376268 | 0.89 | TPMT (0.42) | RARBALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL914005 | 0.87 | RARB (0.59) | RARBCTRCALDH1A1MEN1MAPT | |
| SCHEMBL9701286 | 0.87 | RARB (0.59) | RARBCTRCALDH1A1MEN1MAPT | |
| SCHEMBL27854912 | 0.85 | GPR84 (0.41) | RARBALDH1A1HPGDHSD17B10GPR84 | |
| SCHEMBL2725031 | 0.82 | ALDH1A1 (0.50) | ALDH1A1MEN1MAPTKMT2AHPGD | |
| Octane SCHEMBL7266397 | 0.82 | PLA2G2A (0.56) | RARBALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL27782228 | 0.82 | GPR84 (0.61) | RARBALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL32679274 | 0.82 | ALDH1A1 (0.50) | ALDH1A1MEN1MAPTKMT2AHPGD | |
| SCHEMBL8413501 | 0.82 | RARB (0.61) | RARBALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL25402608 | 0.81 | PTGS2 (0.58) | RARBCTRCALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379513-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010078408-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | BIOGEN IDEC MA INC. (US) | 2010-07-08 | — | — | WO | disclosed |