Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 4/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 11/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | ICMT | O60725 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2492205 | 0.89 | CHRM1 (0.41) | CHRM1GRIN2BGRIN1 | |
| SCHEMBL2491881 | 0.88 | ERN1 (0.42) | CHRM1GRIN2BGRIN1HDAC6 | |
| SCHEMBL2488465 | 0.88 | CHRM1 (0.41) | CHRM1GRIN2BGRIN1 | |
| SCHEMBL2488023 | 0.86 | CHRM1 (0.54) | CHRM1GRIN2BGRIN1NPC1POLB | |
| SCHEMBL2492208 | 0.84 | CHRM1 (0.41) | CHRM1GRIN2BGRIN1 | |
| SCHEMBL2486084 | 0.84 | CHRM1 (0.53) | CHRM1RXFP1 | |
| SCHEMBL2487909 | 0.84 | CHRM1 (0.43) | CHRM1 | |
| SCHEMBL2488348 | 0.84 | CHRM1 (0.40) | CHRM1GRIN2B | |
| SCHEMBL2487485 | 0.82 | CHRM1 (0.45) | CHRM1GRIN2BGRIN1 | |
| SCHEMBL2487494 | 0.80 | CHRM1 (0.40) | CHRM1ICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |