Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL435035 | 0.84 | KMT2A (0.54) | BRD4BRPF1LMNANPC1KMT2A | |
| SCHEMBL5792305 | 0.75 | MAPT (0.56) | BRD4BRPF1LMNANPC1KMT2A | |
| SCHEMBL627253 | 0.75 | CYP1A2 (0.47) | BRD4BRPF1LMNANPC1KMT2A | |
| SCHEMBL16997529 | 0.74 | HPD (0.47) | BRD4BRPF1LMNANPC1KMT2A | |
| SCHEMBL19657533 | 0.74 | ALDH1A1 (0.49) | NPC1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL19657555 | 0.70 | HPD (0.53) | NPC1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5987420 | 0.69 | ALDH1A1 (0.53) | LMNAKMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5987056 | 0.69 | PIK3CG (0.58) | LMNAKMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL15046536 | 0.68 | MAPT (0.49) | LMNAMAPTPOLBALDH1A1HSD17B10 | |
| SCHEMBL27130527 | 0.67 | MAPT (0.52) | BRD4BRPF1LMNANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230355609-A1 | Spirolactone Compounds | QUIXGEN, INC. (US) | 2023-11-09 | — | — | US | disclosed |
| WO-2023283610-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF IRAK4 PROTEINS | BIOGEN MA INC. (US) | 2023-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230355609-A1 | Spirolactone Compounds | ACACA, AKR1C2, AKR1A1 | BRD4 2711/4885BRPF1 3280/4885LMNA 3974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.