Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PNMT | P11086 | 7/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24891984 | 0.82 | KDM4E (0.38) | HTTALDH1A1GAAHPGDLMNA | |
| SCHEMBL13329206 | 0.76 | KDM4E (0.70) | HTTALDH1A1GAAHPGDLMNA | |
| SCHEMBL13329199 | 0.76 | KDM4E (0.65) | HTTALDH1A1GAAHPGDLMNA | |
| SCHEMBL24892162 | 0.75 | HTT (0.42) | HTTALDH1A1GAAHPGDLMNA | |
| SCHEMBL13329207 | 0.74 | KDM4E (0.68) | HTTALDH1A1GAAHPGDLMNA | |
| SCHEMBL28308550 | 0.71 | NSD2 (0.44) | HTTALDH1A1GAAHPGDLMNA | |
| Hydrochloric Acid SCHEMBL30182966 | 0.70 | SMN1; SMN2 (0.40) | HTTALDH1A1GAAHPGDLMNA | |
| SCHEMBL2826099 | 0.67 | ALDH1A1 (0.48) | HTTALDH1A1GAAHPGDLMNA | |
| SCHEMBL13329203 | 0.67 | ALDH1A1 (0.48) | HTTALDH1A1GAAHPGDLMNA | |
| SCHEMBL23930712 | 0.66 | HTT (0.50) | HTTALDH1A1GAAHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023285583-A1 | 5,6,7,8-TETRAHYDRO-2,6- AND 2,7-NAPHTHYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF DISEASES RESPONSIVE TO CITRATE TRANSPORTER MODULATION | ETERNYGEN UK LTD. (GB) | 2023-01-19 | — | — | WO | disclosed |