Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 7/20 | 0.40 |
| ▸ | F2 | P00734 | 5/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 2/20 | 0.36 |
| ▸ | PLAU | P00749 | 2/20 | 0.36 |
| ▸ | PLAT | P00750 | 2/20 | 0.36 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.36 |
| ▸ | MPL | P40238 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1973743 | 0.84 | MAPT (0.49) | ABCG2MPLCDK8CYP1A2CYP2C9 | |
| SCHEMBL249549 | 0.74 | MPL (0.42) | F10MPLCDK8 | |
| SCHEMBL248689 | 0.71 | TRPA1 (0.45) | MPLCDK8MAPT | |
| SCHEMBL2323118 | 0.68 | ADORA2A (0.67) | MPLCYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL1283223 | 0.66 | ALDH1A1 (0.50) | MPLCDK8MAPT | |
| SCHEMBL18517389 | 0.66 | AR (0.46) | MPL | |
| SCHEMBL7896608 | 0.65 | MEN1 (0.46) | F10MPLCDK8 | |
| SCHEMBL28293168 | 0.64 | MAPT (0.47) | ABCG2CYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL15169905 | 0.64 | DRD1 (0.44) | CDK8CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7776073 | 0.63 | KDR (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367682-B2 | Pyrimidine derivatives and their use as pesticides | NOVARTIS AG (CH) | 2013-02-05 | — | — | US | claimed |
| US-8367682-B2 | Pyrimidine derivatives and their use as pesticides | NOVARTIS AG (CH) | 2013-02-05 | — | — | US | disclosed |
| WO-2012000922-A2 | New Use | NOVARTIS AG (CH) | 2012-01-05 | — | — | WO | disclosed |
| EP-2091924-B1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS PESTICIDES | NOVARTIS AG (CH) | 2011-06-22 | — | — | EP | disclosed |
| US-20100010003-A1 | Pyrimidine Derivatives And Their Use As Pesticides | NOVARTIS TIERGESUNDHEIT AG (CH) | 2010-01-14 | — | — | US | disclosed |
| EP-2091924-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS PESTICIDES | Novartis AG (CH) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008009691-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS PESTICIDES | NOVARTIS AG (CH) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010003-A1 | Pyrimidine Derivatives And Their Use As Pesticides | DPYD, TYMP, TYMS | F10 3418/4885F2 275/4885TNK2 2864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.