Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.45 |
| ▸ | CDK8 | P49336 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 8/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | MPL | P40238 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13531352 | 0.88 | TRPA1 (0.43) | TRPA1CDK8KDREGFRHTR2A | |
| SCHEMBL8194713 | 0.85 | NR3C2 (0.40) | TRPA1CDK8KDREGFRHTR2A | |
| SCHEMBL249549 | 0.82 | MPL (0.42) | CDK8KDRMPLHTR2ASLC6A4 | |
| SCHEMBL3368874 | 0.81 | EGFR (0.44) | TRPA1CDK8KDREGFRHTR2A | |
| SCHEMBL15170241 | 0.81 | EGFR (0.44) | TRPA1CDK8KDREGFRHTR2A | |
| SCHEMBL13542475 | 0.80 | ALDH1A1 (0.50) | CDK8KDRMAPTAR | |
| SCHEMBL3366738 | 0.80 | EGFR (0.46) | KDREGFRHTR2ASLC6A4KCNH2 | |
| SCHEMBL6938479 | 0.80 | KDR (0.48) | CDK8KDRHTR2ASLC6A4KCNH2 | |
| SCHEMBL1283223 | 0.79 | ALDH1A1 (0.50) | CDK8MPLHTR2ASLC6A4KCNH2 | |
| SCHEMBL3929860 | 0.79 | CDK8 (0.41) | TRPA1CDK8KDRHTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090197902-A1 | Use of Pyrimidine Compounds in the Preparation of Parasiticides | NOVARTIS AG (CH) | 2009-08-06 | — | — | US | claimed |
| US-8759564-B2 | Amidoacetonitrile compounds having pesticidal activity | NOVARTIS AG (CH) | 2014-06-24 | — | — | US | disclosed |
| US-8367682-B2 | Pyrimidine derivatives and their use as pesticides | NOVARTIS AG (CH) | 2013-02-05 | — | — | US | disclosed |
| US-20120232138-A1 | AMIDOACETONITRILE COMPOUNDS HAVING PESTICIDAL ACTIVITY | NOVARTIS AG (CH) | 2012-09-13 | — | — | US | disclosed |
| WO-2012000922-A2 | New Use | NOVARTIS AG (CH) | 2012-01-05 | — | — | WO | disclosed |
| EP-2091924-B1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS PESTICIDES | NOVARTIS AG (CH) | 2011-06-22 | — | — | EP | disclosed |
| US-20100010003-A1 | Pyrimidine Derivatives And Their Use As Pesticides | NOVARTIS TIERGESUNDHEIT AG (CH) | 2010-01-14 | — | — | US | disclosed |
| EP-2091924-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS PESTICIDES | Novartis AG (CH) | 2009-08-26 | — | — | EP | disclosed |
| US-20090197902-A1 | Use of Pyrimidine Compounds in the Preparation of Parasiticides | NOVARTIS AG (CH) | 2009-08-06 | — | — | US | disclosed |
| WO-2008009691-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS PESTICIDES | NOVARTIS AG (CH) | 2008-01-24 | — | — | WO | disclosed |
| US-20070155757-A1 | Use of pyrimidine compounds in the preparation of parasiticides | FRUCHTEL JORG | 2007-07-05 | — | — | US | disclosed |
| EP-1725539-A1 | USE OF PYRIMIDINE COMPOUNDS IN THE PREPARATION OF PARASITICIDES | Novartis AG (CH) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005085211-A1 | USE OF PYRIMIDINE COMPOUNDS IN THE PREPARATION OF PARASITICIDES | NOVARTIS AG (CH) | 2005-09-15 | — | — | WO | disclosed |
| EP-1574502-A1 | Use of pyrimidine compounds in the preparation of parasiticides | Novartis AG (CH) | 2005-09-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197902-A1 | Use of Pyrimidine Compounds in the Preparation of Parasiticides | TYMP, TYMS, P2RX1 | TRPA1 2491/4885CDK8 1102/4885KDR 2172/4885 |
| US-20100010003-A1 | Pyrimidine Derivatives And Their Use As Pesticides | DPYD, TYMP, TYMS | TRPA1 1070/4885CDK8 2680/4885KDR 3180/4885 |
| US-20070155757-A1 | Use of pyrimidine compounds in the preparation of parasiticides | TYMP, TYMS, P2RX1 | TRPA1 2491/4885CDK8 1102/4885KDR 2172/4885 |
| US-20120232138-A1 | AMIDOACETONITRILE COMPOUNDS HAVING PESTICIDAL ACTIVITY | ACHE, NAAA, NIT2 | TRPA1 194/4885CDK8 2116/4885KDR 4489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.