Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 3/20 | 0.42 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 4/20 | 0.35 |
| ▸ | FLT1 | P17948 | 2/20 | 0.35 |
| ▸ | FLT4 | P35916 | 2/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL248689 | 0.82 | TRPA1 (0.45) | MPLCDK8HTR2ASLC6A4KCNH2 | |
| SCHEMBL1973743 | 0.81 | MAPT (0.49) | MPLCDK8AR | |
| SCHEMBL1283223 | 0.77 | ALDH1A1 (0.50) | MPLCDK8HTR2ASLC6A4KCNH2 | |
| SCHEMBL7896608 | 0.75 | MEN1 (0.46) | MPLCDK8HTR2ASLC6A4KCNH2 | |
| SCHEMBL248970 | 0.74 | F10 (0.40) | MPLCDK8F10 | |
| SCHEMBL13531352 | 0.73 | TRPA1 (0.43) | CDK8HTR2ASLC6A4KCNH2AR | |
| SCHEMBL20139790 | 0.71 | HTR2A (0.39) | MPLHTR2ASLC6A4KCNH2AR | |
| SCHEMBL27845525 | 0.71 | CDK8 (0.44) | MPLCDK8HTR2ASLC6A4KCNH2 | |
| SCHEMBL3457149 | 0.70 | MAPK1 (0.45) | MPLCDK8HTR2ASLC6A4KCNH2 | |
| SCHEMBL2323118 | 0.70 | ADORA2A (0.67) | MPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367682-B2 | Pyrimidine derivatives and their use as pesticides | NOVARTIS AG (CH) | 2013-02-05 | — | — | US | disclosed |
| WO-2012000922-A2 | New Use | NOVARTIS AG (CH) | 2012-01-05 | — | — | WO | disclosed |
| EP-2091924-B1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS PESTICIDES | NOVARTIS AG (CH) | 2011-06-22 | — | — | EP | disclosed |
| US-20100010003-A1 | Pyrimidine Derivatives And Their Use As Pesticides | NOVARTIS TIERGESUNDHEIT AG (CH) | 2010-01-14 | — | — | US | disclosed |
| EP-2091924-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS PESTICIDES | Novartis AG (CH) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008009691-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS PESTICIDES | NOVARTIS AG (CH) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010003-A1 | Pyrimidine Derivatives And Their Use As Pesticides | DPYD, TYMP, TYMS | MPL 2700/4885CDK8 2680/4885HTR2A 4275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.