Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL368273 | 0.91 | LMNA (0.57) | LMNASMN1; SMN2USP2NPC1RAB9A | |
| SCHEMBL183586 | 0.85 | ALDH1A1 (0.47) | LMNASMN1; SMN2USP2NPC1RAB9A | |
| SCHEMBL6825744 | 0.81 | ALDH1A1 (0.35) | LMNASMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL11801214 | 0.80 | SLC6A2 (0.40) | LMNASMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL31677770 | 0.80 | — | — | |
| SCHEMBL10163734 | 0.76 | SMN1; SMN2 (0.60) | LMNASMN1; SMN2USP2NPC1RAB9A | |
| SCHEMBL16021071 | 0.76 | ALDH1A1 (0.44) | LMNASMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL26164112 | 0.74 | TDP1 (0.44) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL13789085 | 0.74 | MTNR1A (0.38) | LMNASMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL14514536 | 0.73 | EPHX1 (0.50) | NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023288242-A1 | PI3Kα INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2023-01-19 | — | — | WO | disclosed |