Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.43 |
| ▸ | MAPT | P10636 | 14/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.43 |
| ▸ | HPGD | P15428 | 9/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5420863 | 0.78 | ALDH1A1 (0.41) | ALDH1A1MAPTKDM4EHPGDALOX15 | |
| SCHEMBL6120984 | 0.77 | ALDH1A1 (0.42) | ALDH1A1MAPTKDM4EHPGDALOX15 | |
| SCHEMBL10720075 | 0.77 | ALDH1A1 (0.43) | ALDH1A1MAPTKDM4EHPGDALOX15 | |
| SCHEMBL17909966 | 0.73 | ALDH1A1 (0.44) | ALDH1A1MAPTKDM4EHPGDALOX15 | |
| SCHEMBL8290782 | 0.69 | ALDH1A1 (0.53) | ALDH1A1MAPTKDM4EHPGDALOX15 | |
| SCHEMBL11533490 | 0.67 | OAT (0.33) | — | |
| SCHEMBL644159 | 0.66 | ALDH1A1 (0.73) | ALDH1A1MAPTKDM4EHPGDALOX15 | |
| SCHEMBL11479163 | 0.66 | ALDH1A1 (0.73) | ALDH1A1MAPTKDM4EHPGDALOX15 | |
| SCHEMBL15832849 | 0.66 | ALDH1A1 (0.40) | ALDH1A1MAPTKDM4EHPGDALOX15 | |
| SCHEMBL11485336 | 0.65 | ALDH1A1 (0.74) | ALDH1A1MAPTKDM4EHPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150530-B1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2150530-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008131947-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |
| EP-0227431-A1 | Heterocyclic amides | BEECHAM GROUP PLC (GB) | 1987-07-01 | — | — | EP | disclosed |