Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 12/20 | 0.43 |
| ▸ | ITGAV | P06756 | 12/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL860740 | 0.88 | LTA4H (0.42) | LTA4HPPARDITGB3ITGAVHDAC1 | |
| SCHEMBL860659 | 0.75 | ITGB3 (0.56) | ITGB3ITGAVITGB5ITGB1ITGB6 | |
| SCHEMBL3140159 | 0.73 | SMN1; SMN2 (0.38) | — | |
| SCHEMBL5823603 | 0.72 | FGFR4 (0.36) | — | |
| SCHEMBL4247556 | 0.71 | ITGB3 (0.60) | ITGB3ITGAVITGB5 | |
| SCHEMBL20141262 | 0.70 | FGFR4 (0.39) | — | |
| SCHEMBL21328960 | 0.70 | ITGAV (0.37) | ITGB3ITGAVITGB5ITGB6 | |
| SCHEMBL4243065 | 0.70 | ITGB3 (0.56) | ITGB3ITGAVITGB5 | |
| SCHEMBL19953633 | 0.70 | PPARG (0.47) | PPARDITGB3ITGAVITGB5ITGB1 | |
| SCHEMBL19953632 | 0.70 | PPARG (0.47) | PPARDITGB3ITGAVITGB5ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425010-B1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | ORTHO MCNEIL PHARM INC (US) | 2011-10-26 | — | — | EP | disclosed |
| EP-1425010-A4 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | ORTHO MCNEIL PHARM INC (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-1425010-A1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2002060438-A1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2002-08-08 | — | — | WO | disclosed |