SCHEMBL24899728

SCHEMBL24899728

CS(=N)(=O)c1ccc(I)nc1

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 12/20 0.35
CDK2 P24941 12/20 0.35
KDR P35968 9/20 0.35
ENPP2 Q13822 1/20 0.34
DRD1 P21728 1/20 0.34
KDM4E B2RXH2 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
OGA O60502 1/20 0.32
MAPT P10636 1/20 0.32
GPR119 Q8TDV5 1/20 0.31
GCKR Q14397 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9881056 0.83 ENPP2 (0.41) ENPP2KDM4EGPR119
SCHEMBL24899755 0.79 SMN1; SMN2 (0.37) CDK1CDK2KDRKDM4ESMN1; SMN2
SCHEMBL24899759 0.79 ALDH1A1 (0.32) KDM4ESMN1; SMN2
SCHEMBL24899761 0.79 HSD17B10 (0.34) KDM4ESMN1; SMN2MAPT
SCHEMBL24899723 0.77 DRD1 (0.37) CDK1CDK2KDRDRD1KDM4E
SCHEMBL24899758 0.77 MAPT (0.34) CDK1CDK2KDRDRD1KDM4E
SCHEMBL23625111 0.76 KDM4E (0.60) KDM4ESMN1; SMN2GCKR
SCHEMBL3086532 0.76 SMN1; SMN2 (0.56) KDM4ESMN1; SMN2MAPT
SCHEMBL24899756 0.75 CA2 (0.44) KDM4E
SCHEMBL24899887 0.74 HSD17B10 (0.49) KDM4ESMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023284869-A1 SULFUR/PHOSPHORUS-CONTAINING ARYL COMPOUND AND APPLICATION THEREOF 南京明德新药研发有限公司 2023-01-19 WO disclosed