Sugi Predict

Sugi Predict / Compounds / SCHEMBL3086532

SCHEMBL3086532

SCHEMBL3086532

CS(=N)(=O)c1ccc(Cl)nc1

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 2/20 0.56
▸ MAPT P10636 1/20 0.54
▸ POLB P06746 1/20 0.49
▸ ALDH1A1 P00352 7/20 0.46
▸ MEN1 O00255 2/20 0.46
▸ KMT2A Q03164 2/20 0.46
▸ CYP2D6 P10635 1/20 0.46
▸ TDP1 Q9NUW8 1/20 0.45
▸ L3MBTL1 Q9Y468 1/20 0.45
▸ GAA P10253 2/20 0.44
▸ PKM P14618 2/20 0.44
▸ CYP2C19 P33261 1/20 0.42
▸ LMNA P02545 1/20 0.41
▸ MAPK1 P28482 1/20 0.41
▸ EGFR P00533 1/20 0.41
▸ KDM4E B2RXH2 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29977958 0.83 SMN1; SMN2 (0.59) SMN1; SMN2MAPTPOLBALDH1A1MEN1
SCHEMBL1256644 0.83 SMN1; SMN2 (0.59) SMN1; SMN2MAPTPOLBALDH1A1MEN1
SCHEMBL23904091 0.82 SMN1; SMN2 (0.53) SMN1; SMN2MAPTPOLBALDH1A1MEN1
SCHEMBL23845573 0.81 MAPT (0.60) SMN1; SMN2MAPTPOLBALDH1A1MEN1
SCHEMBL26786372 0.80 SMN1; SMN2 (0.51) SMN1; SMN2MAPTPOLBALDH1A1MEN1
SCHEMBL23833598 0.79 SMN1; SMN2 (0.60) SMN1; SMN2MAPTPOLBALDH1A1MEN1
SCHEMBL23845463 0.77 SMN1; SMN2 (0.53) SMN1; SMN2MAPTPOLBALDH1A1MEN1
SCHEMBL23845470 0.77 ALDH1A1 (0.54) SMN1; SMN2MAPTPOLBALDH1A1MEN1
SCHEMBL17509 0.77 SMN1; SMN2 (0.56) SMN1; SMN2MAPTPOLBALDH1A1MEN1
SCHEMBL29483829 0.77 SMN1; SMN2 (0.56) SMN1; SMN2MAPTPOLBALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12459922-B2 PARP7 inhibitors GILEAD SCIENCES, INC. (US) 2025-11-04 — — US disclosed
EP-4469448-A1 PARP7 INHIBITORS GILEAD SCIENCES, INC. (US) 2024-12-04 — — EP disclosed
US-20230365529-A1 PARP7 INHIBITORS GILEAD SCIENCES, INC. 2023-11-16 — — US disclosed
US-20230365529-A1 PARP7 INHIBITORS GILEAD SCIENCES, INC. 2023-11-16 — — US disclosed
WO-2023147418-A1 PARP7 INHIBITORS GILEAD SCIENCES, INC. (US) 2023-08-03 — — WO disclosed
WO-2023147418-A1 PARP7 INHIBITORS GILEAD SCIENCES, INC. (US) 2023-08-03 — — WO disclosed
US-20230212138-A1 PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND THEIR USE AKEBIA THERAPEUTICS, INC. (US) 2023-07-06 — — US disclosed
US-20230212138-A1 PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND THEIR USE AKEBIA THERAPEUTICS, INC. (US) 2023-07-06 — — US disclosed
US-20230159489-A1 PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND USE AKEBIA THERAPEUTICS, INC. (US) 2023-05-25 — — US disclosed
US-20230159489-A1 PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND USE AKEBIA THERAPEUTICS, INC. (US) 2023-05-25 — — US disclosed
US-7829719-B2 Insecticidal N-substituted sulfoximines DOW AGROSCIENCES LLC (US) 2010-11-09 — — US disclosed
US-7795456-B2 Insecticidal N-substituted sulfoximines DOW AGROSCIENCES LLC (US) 2010-09-14 — — US disclosed
US-20100076032-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES DOW AGROSCIENCES LLC (US) 2010-03-25 — — US disclosed
US-7678920-B2 Insecticidal N-substituted sulfoximines DOW AGROSCIENCES LLC (US) 2010-03-16 — — US disclosed
US-20100063136-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES DOW AGROSCIENCES LLC (US) 2010-03-11 — — US disclosed
US-20100056578-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES DOW AGROSCIENCES LLC (US) 2010-03-04 — — US disclosed
US-20100056579-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES DOW AGROSCIENCES LLC (US) 2010-03-04 — — US disclosed
EP-1732895-A2 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES Dow Agrosciences LLC (US) 2006-12-20 — — EP disclosed
WO-2006060029-A2 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES DOW AGROSCIENCES LLC (US) 2006-06-08 — — WO disclosed
US-20050228027-A1 Insecticidal N-substituted sulfoximines CORTEVA AGRISCIENCE LLC 2005-10-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100056579-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES GSS, STS, SMS SMN1; SMN2 253/4885MAPT 4687/4885POLB 4421/4885
US-20100076032-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES GSS, STS, SMS SMN1; SMN2 253/4885MAPT 4687/4885POLB 4421/4885
US-12459922-B2 PARP7 inhibitors PARP1, PARP11, PARP2 SMN1; SMN2 2629/4885MAPT 2243/4885POLB 72/4885
US-20230212138-A1 PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND THEIR USE HIF1AN, EGLN3, EGLN2 SMN1; SMN2 4864/4885MAPT 4584/4885POLB 4250/4885
US-20100063136-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES GSS, STS, SMS SMN1; SMN2 253/4885MAPT 4687/4885POLB 4421/4885
US-20230365529-A1 PARP7 INHIBITORS PARP1, PARP11, PARP2 SMN1; SMN2 2629/4885MAPT 2243/4885POLB 72/4885
US-20100056578-A1 INSECTICIDAL N-SUBSTITUTED SULFOXIMINES GSS, STS, SMS SMN1; SMN2 253/4885MAPT 4687/4885POLB 4421/4885
US-20050228027-A1 Insecticidal N-substituted sulfoximines GSS, STS, SMS SMN1; SMN2 253/4885MAPT 4687/4885POLB 4421/4885
US-20230159489-A1 PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND USE HIF1AN, EGLN3, PHF20 SMN1; SMN2 4853/4885MAPT 4498/4885POLB 4290/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.