Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | IGF1R | P08069 | 2/20 | 0.45 |
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | CDK7 | P50613 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30221565 | 1.00 | PDK1 (0.47) | PDK1LCKIGF1RGSK3AGSK3B | |
| SCHEMBL17683181 | 0.91 | ALDH1A1 (0.40) | PDK1LCKIGF1RGSK3AGSK3B | |
| SCHEMBL30957563 | 0.85 | PDK1 (0.49) | PDK1LCKIGF1RGSK3AGSK3B | |
| SCHEMBL24900439 | 0.85 | PDK1 (0.49) | PDK1LCKIGF1RGSK3AGSK3B | |
| SCHEMBL30957591 | 0.85 | EGFR (0.42) | PDK1LCKIGF1RGSK3AGSK3B | |
| SCHEMBL24900433 | 0.85 | PDK1 (0.47) | PDK1LCKIGF1RGSK3AGSK3B | |
| SCHEMBL24900364 | 0.85 | EGFR (0.42) | PDK1LCKIGF1RGSK3AGSK3B | |
| SCHEMBL30957473 | 0.85 | PDK1 (0.47) | PDK1LCKIGF1RGSK3AGSK3B | |
| SCHEMBL24900406 | 0.82 | EGFR (0.51) | PDK1CDK7CDK9CDK5EGFR | |
| SCHEMBL30221531 | 0.82 | EGFR (0.51) | PDK1CDK7CDK9CDK5EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023287783-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | ACEA Therapeutics, Inc. (US) | 2023-01-19 | — | — | WO | disclosed |