Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
| ▸ | BDKRB1 | P46663 | 4/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GNRHR | P30968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL642869 | 0.83 | CACNA1H (0.42) | CACNA1HBDKRB1PTGER3TP53ALDH1A1 | |
| SCHEMBL643833 | 0.82 | BDKRB1 (0.41) | CACNA1HBDKRB1PTGER3 | |
| SCHEMBL645419 | 0.75 | BDKRB1 (0.42) | BDKRB1PTGER3 | |
| SCHEMBL927220 | 0.75 | BDKRB1 (0.51) | BDKRB1PTGER3GAAKMT2A | |
| SCHEMBL2489904 | 0.74 | KMT2A (0.45) | LMNAALDH1A1L3MBTL1GAAKMT2A | |
| SCHEMBL644139 | 0.73 | ALDH1A1 (0.47) | BDKRB1PTGER3LMNAALDH1A1TDP1 | |
| SCHEMBL643004 | 0.73 | ALDH1A1 (0.48) | BDKRB1PTGER3LMNAALDH1A1TDP1 | |
| SCHEMBL643253 | 0.71 | BDKRB1 (0.43) | BDKRB1PTGER3LMNA | |
| SCHEMBL644671 | 0.70 | LMNA (0.43) | BDKRB1PTGER3LMNATP53ALDH1A1 | |
| SCHEMBL4036560 | 0.70 | TRPA1 (0.45) | LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150530-B1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-10-26 | — | — | EP | claimed |
| EP-2150530-B1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2150530-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008131947-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |