Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.34 |
| ▸ | IL1B | P01584 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24906445 | 1.00 | CRHR1 (0.34) | CRHR1IL1BP2RX7HTR2AHTR2C | |
| SCHEMBL24906203 | 0.76 | P2RX7 (0.36) | P2RX7HTR2AHTR2CSLC6A4 | |
| SCHEMBL24758260 | 0.76 | HTR2A (0.33) | HTR2AHTR2CSLC6A4 | |
| SCHEMBL24758976 | 0.73 | AKR1C3 (0.40) | IL1BP2RX7 | |
| SCHEMBL24906446 | 0.73 | AKR1C3 (0.40) | IL1BP2RX7 | |
| SCHEMBL24758262 | 0.72 | KDM5A (0.35) | CRHR1IL1BP2RX7 | |
| SCHEMBL24758348 | 0.70 | CNR1 (0.39) | P2RX7HTR2AHTR2CSLC6A4AR | |
| SCHEMBL24906428 | 0.69 | AKR1C3 (0.40) | IL1BP2RX7HTR2A | |
| SCHEMBL30141388 | 0.69 | AKR1C3 (0.40) | IL1BP2RX7HTR2A | |
| SCHEMBL24758261 | 0.68 | P2RX7 (0.40) | P2RX7HTR2AHTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | disclosed |