SCHEMBL643987

SCHEMBL643987

Cn1cc(NCC(=O)O)c(=O)[nH]c1=O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.39
CYP2C9 P11712 2/20 0.36
KMT2A Q03164 2/20 0.36
MAPT P10636 1/20 0.36
HTT P42858 1/20 0.33
CYP1A2 P05177 3/20 0.33
CYP2C19 P33261 3/20 0.33
GAA P10253 1/20 0.33
MEN1 O00255 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
DAO P14920 2/20 0.32
LMNA P02545 1/20 0.32
CYP3A4 P08684 1/20 0.32
MAPK1 P28482 1/20 0.32
PMP22 Q01453 1/20 0.32
APEX1 P27695 1/20 0.32
GRIN2D O15399 1/20 0.32
GRIN3B O60391 1/20 0.32
GRIN1 Q05586 1/20 0.32
GRIN2A Q12879 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6037466 0.84 PARP1 (0.38) PARP1KMT2ADAOGRIN2DGRIN3B
SCHEMBL9109572 0.73 PARP1 (0.36) PARP1KMT2AMAPTMEN1LMNA
SCHEMBL214501 0.71 L3MBTL1 (0.40) CYP2C9KMT2AMAPTHTTCYP1A2
SCHEMBL8672229 0.68 KMT2A (0.45) CYP2C9KMT2AMAPTHTTCYP1A2
SCHEMBL4961428 0.68 LMNA (0.54) PARP1KMT2AMAPTCYP1A2GAA
SCHEMBL643988 0.68 PARP1 (0.39) PARP1MAPTHTTLMNACYP3A4
SCHEMBL26968954 0.68 PYGM (0.61)
SCHEMBL25424962 0.66 KMT2A (0.42) CYP2C9KMT2AMAPTHTTCYP1A2
SCHEMBL2986044 0.65 DAO (0.46) CYP2C9KMT2AMAPTHTTCYP1A2
SCHEMBL2640720 0.65 PARP1 (0.37) PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4658317-A1 PROGRAMMABLE DNA PROTEOLYSIS TARGET CHIMERAS AND METHODS OF THEIR USE Arizona Board of Regents on behalf of Arizona State University (US) 2025-12-10 EP disclosed
WO-2025015018-A1 CONDITIONAL PROTEOLYSIS GENE SILENCING TARGETING CHIMERA AND METHODS OF USE THEREOF ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2025-01-16 WO disclosed
WO-2024163374-A1 PROGRAMMABLE DNA PROTEOLYSIS TARGET CHIMERAS AND METHODS OF THEIR USE ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2024-08-08 WO disclosed
CN-110114058-A Improved ICE-based lipid nanoparticle formulations for delivery of MRNA 川斯勒佰尔公司 2019-08-09 CN disclosed
CN-109996889-A Affine-oligonucleotide conjugates and application thereof 阿布维特罗有限责任公司 2019-07-09 CN disclosed
CN-109312313-A For treating the mRNA therapy of ornithine transcarbamylase deficiency disease 川斯勒佰尔公司 2019-02-05 CN disclosed
CN-109072223-A Polymer code nucleic acid and application thereof 川斯勒佰尔公司 2018-12-21 CN disclosed
US-20180000973-A1 AGENTS FOR USE IN THE DETECTION OF NUCLEASE ACTIVITY HERNÁNDEZ HINCAPIÉ, Frank J. (ES) 2018-01-04 US disclosed
EP-3209335-A1 AGENTS FOR USE IN THE DETECTION OF NUCLEASE ACTIVITY Hernández Hincapié, Frank J. (ES) 2017-08-30 EP disclosed
US-9534034-B2 Methods of modulating apoptosis by administration of relaxin agonists or antagonists MOLECULAR MEDICINE RESEARCH INSTITUTE (US) 2017-01-03 US disclosed
EP-1220896-A4 NOVEL HUMAN LIPASE PROTEINS, NUCLEIC ACIDS ENCODING THEM, AND USES OF BOTH OF THESE MILLENIUM PHARMACEUTICALS INC (US) 2003-04-16 EP disclosed
US-20030045489-A1 Methods for modulating angiogenesis BAYER PHARMACEUTICALS CORPORATION 2003-03-06 US disclosed
US-20020090706-A1 Human RRN3 and compositions and methods relating thereto NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2002-07-11 US disclosed
EP-1220896-A1 NOVEL HUMAN LIPASE PROTEINS, NUCLEIC ACIDS ENCODING THEM, AND USES OF BOTH OF THESE MILLENIUM PHARMACEUTICALS, INC. (US) 2002-07-10 EP disclosed
WO-2002041911-A2 USE OF FGF-19 FOR INHIBITING ANGIOGENESIS BAYER CORPORATION (US) 2002-05-30 WO disclosed
WO-2002028418-A1 METHODS OF MODULATING APOPTOSIS BY ADMINISTRATION OF RELAXIN AGONISTS OR ANTAGONISTS MOLECULAR MEDICINE RESEARCH INSTITUTE (US) 2002-04-11 WO disclosed
EP-1192181-A1 METHODS FOR MODULATING ANGIOGENESIS BY USING THE ANTI-ANGIOGENIC ANGIOTENSIN-7 AND POLYNUCLEOTIDES ENCODING THEREFOR BAYER AG (DE) 2002-04-03 EP disclosed
WO-2001025409-A1 NOVEL HUMAN LIPASE PROTEINS, NUCLEIC ACIDS ENCODING THEM, AND USES OF BOTH OF THESE MILLENIUM PHARMACEUTICALS, INCORPORATED (US) 2001-04-12 WO disclosed
WO-2001002434-A1 METHODS FOR MODULATING ANGIOGENESIS BY USING THE ANTI-ANGIOGENIC ANGIOTENSIN-7 AND POLYNUCLEOTIDES ENCODING THEREFOR BAYER AG (DE) 2001-01-11 WO disclosed
WO-1994000472-A2 TRIVALENT SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING STEREOSPECIFIC ALKYLPHOSPHONATES AND ARYLPHOSPHONATES RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 1994-01-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180000973-A1 AGENTS FOR USE IN THE DETECTION OF NUCLEASE ACTIVITY RNASE1, DNASE1, DCLRE1B PARP1 417/4885CYP2C9 4162/4885KMT2A 2535/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.