Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP3 | P15309 | 3/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2494300 | 0.81 | KIF11 (0.37) | ACP3CES2 | |
| SCHEMBL11156832 | 0.77 | ACP3 (0.44) | ACP3CES2PNMTIDO1TDO2 | |
| SCHEMBL23628841 | 0.76 | TSHR (0.38) | TSHRMAPK1 | |
| SCHEMBL4068170 | 0.76 | TSHR (0.38) | TSHRMAPK1 | |
| SCHEMBL15331089 | 0.74 | ACP3 (0.50) | ACP3CES2PNMTIDO1TDO2 | |
| SCHEMBL6970288 | 0.74 | ACP3 (0.50) | ACP3CES2PNMTIDO1TDO2 | |
| SCHEMBL5990120 | 0.71 | CES2 (0.43) | ACP3CES2PNMTIDO1TDO2 | |
| SCHEMBL17515119 | 0.71 | DAO (0.49) | ACP3CES2PNMTIDO1TDO2 | |
| SCHEMBL9570750 | 0.71 | ACP3 (0.47) | ACP3CES2PNMTIDO1TDO2 | |
| SCHEMBL1712441 | 0.71 | PNMT (0.56) | ACP3CES2PNMTIDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379543-A2 | THIAZOLYL-BENZIMIDAZOLES | F. Hoffmann-La Roche AG (CH) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010121675-A2 | THIAZOLYL-BENZIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |