Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 5/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2488269 | 0.95 | PSEN1 (0.35) | ALDH1A1MAPTPSEN1PSEN2APH1B | |
| SCHEMBL2490758 | 0.94 | SPPL2A (0.36) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2487478 | 0.89 | ALDH1A1 (0.34) | ALDH1A1MAPTCNR2LMNAGAA | |
| SCHEMBL2487066 | 0.84 | SPPL2A (0.36) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL643082 | 0.83 | MAPT (0.36) | ALDH1A1MAPTCNR2LMNAGAA | |
| SCHEMBL644426 | 0.78 | LMNA (0.35) | ALDH1A1MAPTCNR2LMNAGAA | |
| SCHEMBL643063 | 0.74 | CXCR3 (0.42) | ALDH1A1LMNASMN1; SMN2CXCR3KMT2A | |
| SCHEMBL642926 | 0.73 | OPRL1 (0.34) | ALDH1A1MAPTPSEN1PSEN2APH1B | |
| SCHEMBL493188 | 0.73 | SPPL2A (0.36) | ALDH1A1MAPTPSEN1PSEN2APH1B | |
| SCHEMBL644323 | 0.72 | KIF11 (0.39) | ALDH1A1MAPTCNR2LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150530-B1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2150530-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008131947-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |