SCHEMBL24909405

SCHEMBL24909405

N#Cc1cc(-c2csc(C#N)c2)c(O)c(C(F)(F)F)c1

nearest known ligand 0.34

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
XDH P47989 2/20 0.34
SLC22A12 Q96S37 2/20 0.34
KIF11 P52732 1/20 0.33
AR P10275 8/20 0.33
PGR P06401 6/20 0.33
TRPA1 O75762 1/20 0.32
TRPV4 Q9HBA0 1/20 0.32
NR3C1 P04150 3/20 0.31
TTR P02766 2/20 0.31
ALB P02768 2/20 0.31
NR3C2 P08235 2/20 0.31
P4HB P07237 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
CYP2C9 P11712 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24909418 0.86 PDE3B (0.34) XDHSLC22A12KIF11ARPGR
SCHEMBL24910075 0.85 TRPV4 (0.34) XDHSLC22A12KIF11ARPGR
SCHEMBL24909910 0.83 KIF11 (0.34) XDHSLC22A12KIF11ARPGR
SCHEMBL24909915 0.78 KIF11 (0.41) XDHSLC22A12KIF11ARPGR
SCHEMBL24909404 0.78 TMIGD3 (0.36) XDHSLC22A12KIF11ARPGR
SCHEMBL24909806 0.77 TRPV4 (0.33) XDHSLC22A12KIF11ARPGR
SCHEMBL24909781 0.77 PDE3B (0.37) XDHSLC22A12KIF11ARPGR
SCHEMBL24909804 0.77 IDH1 (0.40) XDHSLC22A12KIF11ARTRPV4
SCHEMBL24909774 0.77 KIF11 (0.40) XDHSLC22A12KIF11ARPGR
SCHEMBL24909934 0.75 KIF11 (0.45) XDHSLC22A12KIF11ARPGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230024283-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2023-01-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230024283-A1 HERBICIDAL COMPOUNDS DDT, CBR3, GLRX3 XDH 662/4885SLC22A12 1281/4885KIF11 2192/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.