SCHEMBL24909774

SCHEMBL24909774

N#Cc1cc(F)cc(-c2cc(C#N)cc(C(F)(F)F)c2O)c1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.40
LRRK2 Q5S007 1/20 0.36
XDH P47989 1/20 0.36
SLC22A12 Q96S37 1/20 0.36
GRM5 P41594 2/20 0.36
AR P10275 4/20 0.36
PGR P06401 5/20 0.35
VEGFA P15692 1/20 0.35
TRPV4 Q9HBA0 1/20 0.35
MAP4K4 O95819 1/20 0.35
TTR P02766 2/20 0.34
ALB P02768 2/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24909915 0.95 KIF11 (0.41) KIF11XDHSLC22A12ARPGR
SCHEMBL24909727 0.88 KIF11 (0.36) KIF11XDHSLC22A12GRM5AR
SCHEMBL24909923 0.88 KIF11 (0.36) KIF11XDHSLC22A12ARPGR
SCHEMBL24909762 0.86 RXRA (0.46) KIF11XDHSLC22A12ARPGR
SCHEMBL24909934 0.86 KIF11 (0.45) KIF11XDHSLC22A12ARPGR
SCHEMBL24909754 0.85 AR (0.40) KIF11LRRK2GRM5ARPGR
SCHEMBL24910014 0.85 KIF11 (0.38) KIF11XDHSLC22A12ARPGR
SCHEMBL24910011 0.84 AR (0.43) KIF11XDHSLC22A12ARPGR
SCHEMBL24910055 0.82 PDK2 (0.44) KIF11XDHSLC22A12ARPGR
SCHEMBL24909891 0.81 AR (0.43) LRRK2XDHSLC22A12GRM5AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230024283-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2023-01-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230024283-A1 HERBICIDAL COMPOUNDS DDT, CBR3, GLRX3 KIF11 2192/4885LRRK2 2146/4885XDH 662/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.