SCHEMBL24909727

SCHEMBL24909727

N#Cc1cc(-c2cc(F)cc(Cl)c2)c(O)c(C(F)(F)F)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.36
SSTR2 P30874 1/20 0.35
TRPV4 Q9HBA0 1/20 0.35
GRM5 P41594 2/20 0.34
XDH P47989 2/20 0.34
SLC22A12 Q96S37 2/20 0.34
CYP1A2 P05177 1/20 0.34
AR P10275 4/20 0.33
PGR P06401 1/20 0.33
GYS1 P13807 1/20 0.32
NR3C1 P04150 1/20 0.32
NR3C2 P08235 1/20 0.32
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
GLA P06280 1/20 0.32
GAA P10253 1/20 0.32
HPGD P15428 1/20 0.32
HTT P42858 1/20 0.32
TRPA1 O75762 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24909915 0.90 KIF11 (0.41) KIF11TRPV4XDHSLC22A12AR
SCHEMBL24909774 0.88 KIF11 (0.40) KIF11TRPV4GRM5XDHSLC22A12
SCHEMBL24909923 0.83 KIF11 (0.36) KIF11SSTR2TRPV4XDHSLC22A12
SCHEMBL24909729 0.83 KDM4E (0.43) KIF11TRPV4XDHSLC22A12AR
SCHEMBL24910040 0.82 TRPV4 (0.35) KIF11TRPV4XDHSLC22A12AR
SCHEMBL24909934 0.81 KIF11 (0.45) KIF11TRPV4XDHSLC22A12AR
SCHEMBL24909739 0.81 KIF11 (0.43) KIF11TRPV4XDHSLC22A12AR
SCHEMBL24909754 0.80 AR (0.40) KIF11SSTR2GRM5ARPGR
SCHEMBL24910014 0.80 KIF11 (0.38) KIF11TRPV4XDHSLC22A12AR
SCHEMBL24909822 0.80 TTR (0.51) SSTR2GRM5CYP1A2PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230024283-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2023-01-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230024283-A1 HERBICIDAL COMPOUNDS DDT, CBR3, GLRX3 KIF11 2192/4885SSTR2 1646/4885TRPV4 2634/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.