SCHEMBL24916459

SCHEMBL24916459

C/N=C\c1ccccc1NC(C)(C)C

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.38
ELANE P08246 2/20 0.35
PRTN3 P24158 1/20 0.35
MAPT P10636 2/20 0.33
GAA P10253 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
ATM Q13315 1/20 0.32
SPHK2 Q9NRA0 1/20 0.31
SPHK1 Q9NYA1 1/20 0.31
LMNA P02545 1/20 0.30
HTT P42858 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13816746 0.78 MAPT (0.40) IDO1MAPTGAARAB9ASMN1; SMN2
SCHEMBL29226190 0.76 LMNA (0.48) IDO1ELANEPRTN3GAASMN1; SMN2
SCHEMBL11032230 0.76 ALDH1A1 (0.40) IDO1ELANEPRTN3MAPTATM
SCHEMBL26665650 0.76 IDO1 (0.40) IDO1ELANEPRTN3MAPTATM
SCHEMBL29881429 0.73 IDO1 (0.52) IDO1MAPTRAB9AATMHTT
SCHEMBL6251669 0.73 IDO1 (0.52) IDO1MAPTRAB9AATMHTT
SCHEMBL19142380 0.73 MAPT (0.37) MAPTGAARAB9ASMN1; SMN2SPHK2
SCHEMBL21204295 0.72 MAPT (0.44) MAPTGAARAB9ASMN1; SMN2LMNA
SCHEMBL24916452 0.72 RRM2 (0.41) IDO1RAB9A
SCHEMBL683597 0.69 IDO1 (0.41) IDO1MAPTGAARAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230026056-A1 ANTIMICROBIAL COMPOUNDS, COMPOSITIONS, AND USES THEREOF Lakewood Amedex, Inc. 2023-01-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230026056-A1 ANTIMICROBIAL COMPOUNDS, COMPOSITIONS, AND USES THEREOF CAT, MPO, NISCH IDO1 2936/4885ELANE 8/4885PRTN3 585/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.