Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24920534 | 0.94 | HSD17B10 (0.45) | HSD17B10CYP2D6TSHRCRBNALDH1A1 | |
| SCHEMBL24920538 | 0.86 | DYRK1A (0.44) | HSD17B10CYP2D6TSHRCRBNALDH1A1 | |
| SCHEMBL24920530 | 0.83 | ALDH1A1 (0.51) | HSD17B10CYP2D6TSHRCRBNALDH1A1 | |
| SCHEMBL24920525 | 0.83 | DYRK1A (0.52) | HSD17B10CYP2D6TSHRCRBNCYP3A4 | |
| SCHEMBL24920533 | 0.82 | HSD17B10 (0.57) | HSD17B10CYP2D6TSHRALDH1A1HPGD | |
| SCHEMBL24920548 | 0.80 | ACHE (0.48) | HSD17B10ALDH1A1CYP1A2AOC3 | |
| SCHEMBL24920567 | 0.80 | DYRK1A (0.38) | HSD17B10CYP2D6TSHRALDH1A1HPGD | |
| SCHEMBL30212567 | 0.79 | HSD17B10 (0.43) | HSD17B10CYP2D6TSHRALDH1A1HPGD | |
| SCHEMBL24921023 | 0.77 | AOC3 (0.44) | AOC3DYRK1A | |
| SCHEMBL24921040 | 0.77 | AOC3 (0.44) | AOC3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006097-A1 | BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-02-02 | — | — | WO | disclosed |