Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 4/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6249005 | 0.82 | CYP11B2 (0.39) | CYP11B2CYP11B1LRRK2PIM1PIM3 | |
| SCHEMBL24921174 | 0.77 | PIM1 (0.43) | PTGDRPIM1PIM3PIM2BRD4 | |
| SCHEMBL24921517 | 0.75 | OXTR (0.36) | PTGDRLRRK2KDM4EBRD4TLR8 | |
| SCHEMBL24921485 | 0.74 | MAOB (0.42) | PTGDRBRD4TLR8TLR7NPC1 | |
| SCHEMBL24920887 | 0.73 | CYP11B2 (0.38) | CYP11B2CYP11B1LRRK2NPC1RAB9A | |
| SCHEMBL24921469 | 0.73 | LRRK2 (0.32) | PTGDRLRRK2BRD4NPC1RAB9A | |
| SCHEMBL24920829 | 0.73 | MAPT (0.41) | CYP11B2CYP11B1LRRK2KDM4EKMT2A | |
| SCHEMBL24920826 | 0.70 | CYP2C19 (0.36) | PTGDRLRRK2PIM1PIM3PIM2 | |
| SCHEMBL24920769 | 0.70 | MAPT (0.40) | CYP11B2CYP11B1LRRK2KDM4ENPC1 | |
| SCHEMBL24920802 | 0.70 | LRRK2 (0.38) | CYP11B2CYP11B1LRRK2PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006097-A1 | BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-02-02 | — | — | WO | disclosed |