Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 8/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31418183 | 0.77 | TSHR (0.40) | MAPTALDH1A1NOTUMKDM4ELMNA | |
| SCHEMBL24921176 | 0.77 | NOTUM (0.54) | MAPTALDH1A1HPGDMAPK1NOTUM | |
| SCHEMBL24921990 | 0.75 | MAPT (0.42) | MAPTALDH1A1HPGDMAPK1NOTUM | |
| SCHEMBL24921991 | 0.74 | ALDH1A1 (0.47) | MAPTALDH1A1HPGDMAPK1NOTUM | |
| SCHEMBL24920799 | 0.73 | CYP11B2 (0.40) | CYP11B2CYP11B1KDM4ELRRK2KMT2A | |
| SCHEMBL6249005 | 0.72 | CYP11B2 (0.39) | CYP11B2CYP11B1KDM4ELRRK2SYK | |
| SCHEMBL24920802 | 0.70 | LRRK2 (0.38) | CYP11B2CYP11B1LRRK2SYK | |
| SCHEMBL24920887 | 0.70 | CYP11B2 (0.38) | MAPTHPGDCYP11B2CYP11B1LMNA | |
| SCHEMBL24920840 | 0.70 | MAPT (0.45) | MAPTALDH1A1HPGDMAPK1NOTUM | |
| SCHEMBL22792303 | 0.70 | NPC1 (0.42) | MAPTALDH1A1HPGDMAPK1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006097-A1 | BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-02-02 | — | — | WO | disclosed |