Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | SYK | P43405 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24921238 | 0.77 | BTK (0.42) | PDE10A | |
| SCHEMBL24921976 | 0.76 | SIRT6 (0.36) | PDE10A | |
| SCHEMBL24920887 | 0.73 | CYP11B2 (0.38) | LRRK2CYP11B2CYP11B1PDE10A | |
| SCHEMBL24920820 | 0.72 | CYP2C19 (0.38) | — | |
| SCHEMBL24921972 | 0.72 | MAOB (0.35) | PDE10A | |
| SCHEMBL24920829 | 0.70 | MAPT (0.41) | LRRK2CYP11B2CYP11B1SYK | |
| SCHEMBL24920799 | 0.70 | CYP11B2 (0.40) | LRRK2CYP11B2CYP11B1PIM1PIM3 | |
| SCHEMBL24920814 | 0.69 | CYP11B2 (0.39) | LRRK2CYP11B2CYP11B1PIM1PIM3 | |
| SCHEMBL6249005 | 0.69 | CYP11B2 (0.39) | LRRK2CYP11B2CYP11B1PIM1PIM3 | |
| SCHEMBL3063023 | 0.69 | CYP11B2 (0.41) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006097-A1 | BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-02-02 | — | — | WO | disclosed |