Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24920864 | 0.76 | MAPT (0.39) | JAK1TYK2NOTUMNPC1RAB9A | |
| SCHEMBL24920831 | 0.76 | LRRK2 (0.36) | LRRK2AOC3 | |
| SCHEMBL30822678 | 0.74 | QPCT (0.40) | LRRK2PTGDRNOTUMBRD4CYP1A2 | |
| SCHEMBL29164610 | 0.74 | QPCT (0.40) | LRRK2PTGDRNOTUMBRD4CYP1A2 | |
| SCHEMBL24920816 | 0.74 | PDE10A (0.31) | CYP1A2MEN1ALDH1A1GLACYP3A4 | |
| SCHEMBL24921547 | 0.74 | NPC1 (0.37) | LRRK2PTGDRJAK1TYK2BRD4 | |
| SCHEMBL24921525 | 0.74 | NPC1 (0.40) | PTGDRBRD4NPC1RAB9AAOC3 | |
| SCHEMBL24920782 | 0.73 | PIM1 (0.36) | LRRK2JAK1TYK2NOTUMBRD4 | |
| SCHEMBL24920776 | 0.73 | L3MBTL1 (0.36) | TRPM8NPC1RAB9AAOC3ALDH1A1 | |
| SCHEMBL24921979 | 0.71 | PTGDR (0.39) | LRRK2PTGDRNOTUMBRD4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006097-A1 | BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-02-02 | — | — | WO | disclosed |