Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 10/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24920807 | 0.76 | LRRK2 (0.36) | NOTUMALDH1A1NPC1RAB9AJAK1 | |
| SCHEMBL24920816 | 0.74 | PDE10A (0.31) | ALDH1A1 | |
| SCHEMBL24921557 | 0.74 | MAPT (0.53) | MAPTNOTUMALDH1A1HPGDMAPK1 | |
| SCHEMBL24921606 | 0.73 | NOTUM (0.47) | MAPTNOTUMALDH1A1HPGDMAPK1 | |
| SCHEMBL24920831 | 0.73 | LRRK2 (0.36) | LMNA | |
| SCHEMBL24920810 | 0.73 | MAPT (0.39) | MAPTNOTUMALDH1A1HPGDMAPK1 | |
| SCHEMBL24921973 | 0.71 | MAPT (0.42) | MAPTNOTUMALDH1A1HPGDMAPK1 | |
| SCHEMBL24920818 | 0.71 | CYP1A2 (0.33) | ALDH1A1HPGDMAPK1TSHR | |
| SCHEMBL21905028 | 0.70 | CYP1A2 (0.37) | ALDH1A1MAPK1TSHR | |
| SCHEMBL24920772 | 0.69 | NOTUM (0.45) | MAPTNOTUMALDH1A1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006097-A1 | BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-02-02 | — | — | WO | disclosed |