Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24920812 | 0.75 | MAPT (0.44) | MAPTRAB9ANPC1SMN1; SMN2NPSR1 | |
| SCHEMBL17109385 | 0.75 | CCR1 (0.58) | CNR2MAPTACHERAB9ANPC1 | |
| SCHEMBL24920833 | 0.74 | PTGDR (0.41) | MAPTPTGDRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL24920815 | 0.73 | CCR1 (0.34) | PDE10A | |
| SCHEMBL17109362 | 0.73 | PDE10A (0.46) | CNR2MAPTACHEPTGDRRAB9A | |
| SCHEMBL24921159 | 0.73 | GABRA5 (0.45) | MAPTACHERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL24921191 | 0.73 | RAB9A (0.48) | MAPTACHERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL24920835 | 0.72 | NOTUM (0.51) | MAPTKMT2AHPGD | |
| SCHEMBL10094731 | 0.71 | RAB9A (0.61) | MAPTACHERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL24921535 | 0.71 | OPRK1 (0.39) | MAPTRAB9ANPC1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006097-A1 | BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-02-02 | — | — | WO | disclosed |