SCHEMBL24920944

SCHEMBL24920944

COC[C@H]1CC[C@H](CN2CCC(CN3CCC4(CC3)CN(C)C4)CC2)CC1

nearest known ligand 0.42

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24920953 1.00 SIGMAR1 (0.37) SIGMAR1
SCHEMBL24940877 0.86 CHRM5 (0.39) SIGMAR1
SCHEMBL24920436 0.83 MEN1 (0.34) SIGMAR1
SCHEMBL22565121 0.82 NCF1 (0.41) SIGMAR1
SCHEMBL22544377 0.82 SIGMAR1 (0.47) SIGMAR1
SCHEMBL27267884 0.81 ACHE (0.37) SIGMAR1
SCHEMBL24920959 0.81 SIGMAR1 (0.42) SIGMAR1
SCHEMBL24920453 0.81 SIGMAR1 (0.42) SIGMAR1
SCHEMBL17887978 0.81 NCF1 (0.42) SIGMAR1
SCHEMBL25571577 0.78 CYP1A2 (0.36) SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023006097-A1 BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER 海创药业股份有限公司 2023-02-02 WO disclosed