Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.35 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.32 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24921238 | 0.76 | BTK (0.42) | MAPTNPC1RAB9APDE10AKDM4E | |
| SCHEMBL24920820 | 0.75 | CYP2C19 (0.38) | MAPTNPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL24921976 | 0.75 | SIRT6 (0.36) | PDE10A | |
| SCHEMBL24921964 | 0.74 | PDE10A (0.31) | PDE10A | |
| SCHEMBL24921577 | 0.74 | CA1 (0.47) | NNMTCA1CA2 | |
| SCHEMBL24922001 | 0.74 | — | — | |
| SCHEMBL24921573 | 0.74 | PDE10A (0.45) | NPC1RAB9ACA1CA2SCD5 | |
| SCHEMBL1456221 | 0.73 | NNMT (0.46) | MAOBNNMTMAPTNPC1RAB9A | |
| SCHEMBL24920802 | 0.72 | LRRK2 (0.38) | PDE10A | |
| SCHEMBL24921491 | 0.70 | ACHE (0.42) | MAOBMAPTNPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006097-A1 | BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-02-02 | — | — | WO | disclosed |