SCHEMBL2492250

SCHEMBL2492250

Cc1cccc(NC([NH])=O)c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.69
KMT2A Q03164 4/20 0.68
MEN1 O00255 3/20 0.68
RXFP1 Q9HBX9 2/20 0.68
KCNK3 O14649 1/20 0.58
KCNH2 Q12809 1/20 0.58
KCNK9 Q9NPC2 1/20 0.58
SMN1; SMN2 Q16637 2/20 0.57
PKM P14618 1/20 0.57
HPGD P15428 1/20 0.57
TP53 P04637 1/20 0.56
MAPT P10636 1/20 0.56
CYP1A2 P05177 2/20 0.56
GAA P10253 1/20 0.56
ALDH1A1 P00352 3/20 0.56
SAE1 Q9UBE0 1/20 0.56
UBA2 Q9UBT2 1/20 0.56
NPSR1 Q6W5P4 1/20 0.56
L3MBTL1 Q9Y468 1/20 0.55
RAB9A P51151 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21567990 0.83 HSD17B10 (0.74) HSD17B10KMT2AMEN1RXFP1KCNK3
SCHEMBL692386 0.83 HSD17B10 (0.74) HSD17B10KMT2AMEN1RXFP1KCNK3
SCHEMBL29703055 0.83 SMN1; SMN2 (0.77) HSD17B10KMT2AMEN1RXFP1KCNK3
SCHEMBL4416620 0.83 SMN1; SMN2 (0.77) HSD17B10KMT2AMEN1RXFP1KCNK3
SCHEMBL30762995 0.83 HSD17B10 (0.74) HSD17B10KMT2AMEN1RXFP1KCNK3
SCHEMBL2908619 0.82 MEN1 (0.89) HSD17B10KMT2AMEN1RXFP1KCNK3
SCHEMBL2099169 0.82 HSD17B10 (0.71) HSD17B10KMT2AMEN1RXFP1KCNK3
SCHEMBL12133 0.82 HSD17B10 (1.00) HSD17B10KMT2AMEN1RXFP1KCNK3
SCHEMBL30703669 0.82 HSD17B10 (1.00) HSD17B10KMT2AMEN1RXFP1KCNK3
Hydrochloric Acid SCHEMBL9576706 0.82 HSD17B10 (0.71) HSD17B10KMT2AMEN1RXFP1KCNK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9198426-B2 Use of 5 pyridin-4-yl-1,3-thiazoles for controlling phytopathogenic fungi BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-12-01 US claimed
EP-2378880-A1 USE OF 5-PYRIDIN-4YL(1,3)THIAZOLE FOR TREATING PHYTOPATHOGENIC FUNGI BAYER CROPSCIENCE AG (DE) 2011-10-26 EP claimed
US-20100168185-A1 Use of 5-pyridin-4-yl-1,3-thiazoles for controlling phytopathogenic fungi BAYER CORPSCIENCE AG (DE) 2010-07-01 US claimed
WO-2010069494-A1 USE OF 5-PYRIDIN-4YL(1,3)THIAZOLE FOR TREATING PHYTOPATHOGENIC FUNGI BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-06-24 WO claimed
EP-2198710-A1 Use of 5-pyridin-4yl-(1,3) thiazoles for combating phytopathogenic fungi Bayer CropScience AG (DE) 2010-06-23 EP claimed
US-9198426-B2 Use of 5 pyridin-4-yl-1,3-thiazoles for controlling phytopathogenic fungi BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-12-01 US disclosed
EP-2378880-A1 USE OF 5-PYRIDIN-4YL(1,3)THIAZOLE FOR TREATING PHYTOPATHOGENIC FUNGI BAYER CROPSCIENCE AG (DE) 2011-10-26 EP disclosed
US-20100168185-A1 Use of 5-pyridin-4-yl-1,3-thiazoles for controlling phytopathogenic fungi BAYER CORPSCIENCE AG (DE) 2010-07-01 US disclosed
WO-2010069494-A1 USE OF 5-PYRIDIN-4YL(1,3)THIAZOLE FOR TREATING PHYTOPATHOGENIC FUNGI BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-06-24 WO disclosed
US-20080167314-A1 Condensed Imidazole Compound And Use Thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-07-10 US disclosed
EP-1832588-A1 CONDENSED IMIDAZOLE COMPOUND AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2007-09-12 EP disclosed
US-5760032-A GASTROINTESTINAL DISORDERS AND NERVOUS SYSTEM DISORDERS YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1998-06-02 US disclosed
US-4085089-A Benzotriazole ultraviolet stabilizing compounds and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-04-18 US disclosed
US-4076687-A Bichromophoric benzotriazole-benzoxazole ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-02-28 US disclosed
US-4075162-A BICHROMOPHORIC BENZOXAZOLE-STYRENE ULTRAVIOLET STABILIZERS AND THEIR USE IN ORGANIC COMPOSITIONS EASTMAN KODAK COMPANY (US) 1978-02-21 US disclosed
US-4073745-A Multichromophoric benzotriazole ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-02-14 US disclosed
US-4070337-A Bichromophoric benzotriazole-styrene ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-01-24 US disclosed
US-4070339-A Bichromophoric benzotriazole-styrene ester ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-01-24 US disclosed
US-4062800-A Bichromophoric benzoxazole-styrene ester and amide ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1977-12-13 US disclosed
US-3981884-A POLYMERS EASTMAN KODAK COMPANY (US) 1976-09-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100168185-A1 Use of 5-pyridin-4-yl-1,3-thiazoles for controlling phytopathogenic fungi PIR, PNPO, PDXK HSD17B10 3028/4885KMT2A 2548/4885MEN1 1783/4885
US-20080167314-A1 Condensed Imidazole Compound And Use Thereof MAPK13, MMP13, MAPK3 HSD17B10 4068/4885KMT2A 2285/4885MEN1 647/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.