SCHEMBL24922883

SCHEMBL24922883

O=C(NCCOCC#Cc1cn([C@H]2CC[C@@H](CO)O2)c(=O)[nH]c1=O)C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.34
ALOX12 P18054 1/20 0.34
ADRA1A P35348 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
ALDH1A1 P00352 1/20 0.33
ALB P02768 1/20 0.33
MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2284109 0.89 LMNA (0.37) LMNAALOX12ADRA1ASMN1; SMN2ALDH1A1
SCHEMBL2276807 0.88 LMNA (0.34) LMNAALOX12ADRA1ASMN1; SMN2ALDH1A1
SCHEMBL9368232 0.87 LMNA (0.36) LMNAALOX12ADRA1ASMN1; SMN2ALDH1A1
SCHEMBL9368222 0.87 LMNA (0.36) LMNAALOX12ADRA1ASMN1; SMN2ALDH1A1
SCHEMBL8476367 0.87 LMNA (0.38) LMNAALOX12ADRA1ASMN1; SMN2ALDH1A1
SCHEMBL8476369 0.87 LMNA (0.38) LMNAALOX12ADRA1ASMN1; SMN2ALDH1A1
SCHEMBL9372470 0.86 LMNA (0.35) LMNAALOX12ADRA1ASMN1; SMN2ALDH1A1
SCHEMBL9372482 0.86 LMNA (0.35) LMNAALOX12ADRA1ASMN1; SMN2ALDH1A1
SCHEMBL7866081 0.85 LMNA (0.53) LMNAALOX12ADRA1ASMN1; SMN2
SCHEMBL7866078 0.85 LMNA (0.53) LMNAALOX12ADRA1ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11649260-B2 Functionalized N-acetylgalactosamine nucleosides HONGENE BIOTECH CORPORATION (US) 2023-05-16 US disclosed
US-20230034284-A1 FUNCTIONALIZED N-ACETYLGALACTOSAMINE NUCLEOSIDES HONGENE BIOTECH CORPORATION 2023-02-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11649260-B2 Functionalized N-acetylgalactosamine nucleosides FUT6, B3GNT2, GALNT6 LMNA 657/4885ALOX12 1988/4885ADRA1A 3290/4885
US-20230034284-A1 FUNCTIONALIZED N-ACETYLGALACTOSAMINE NUCLEOSIDES FUT6, B3GNT2, GALNT6 LMNA 657/4885ALOX12 1988/4885ADRA1A 3290/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.