SCHEMBL24927409

SCHEMBL24927409

Cc1cnn(C(=N)n2cc(CN=C(n3ccc(C(F)(F)F)n3)n3ccc(C(F)(F)F)n3)cn2)c1

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NOS1 P29475 1/20 0.36
ALDH1A1 P00352 2/20 0.31
MAPT P10636 1/20 0.31
MAPK1 P28482 1/20 0.31
MEN1 O00255 1/20 0.31
NPC1 O15118 1/20 0.31
GAA P10253 1/20 0.31
TSHR P16473 1/20 0.31
RAB9A P51151 1/20 0.31
KMT2A Q03164 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
TGM2 P21980 1/20 0.30
TGM1 P22735 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25840818 0.69 NOS1 (0.53) NOS1ALDH1A1MAPTMAPK1MEN1
SCHEMBL22492987 0.68 NOS1 (0.69) NOS1ALDH1A1MAPTMAPK1MEN1
SCHEMBL23638350 0.67 NPC1 (0.37) NOS1MAPTNPC1RAB9A
SCHEMBL16246813 0.62 KLKB1 (0.49)
SCHEMBL28684123 0.61 NOS1 (0.53) NOS1MAPTNPC1RAB9A
SCHEMBL22492989 0.59 NOS1 (0.35) NOS1
SCHEMBL27257093 0.58 PRMT6 (0.36) MAPTNPC1GAARAB9A
SCHEMBL28026546 0.58 LMNA (0.40) MAPTNPC1GAARAB9A
SCHEMBL2725546 0.57 MAPT (0.44) MAPTMAPK1MEN1NPC1RAB9A
SCHEMBL16687029 0.56 SCN4A (0.42) MAPTNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11788080-B2 Modified cleavases, uses thereof and related kits Encodia, Inc. (US) 2023-10-17 US disclosed
US-20230257727-A1 MODIFIED CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2023-08-17 US disclosed
US-20230021091-A1 MODIFIED CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2023-01-19 US disclosed