Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | IDH2 | P48735 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2725546 | 0.78 | MAPT (0.44) | LMNAMAPTNPC1RAB9APOLB | |
| SCHEMBL16687029 | 0.77 | SCN4A (0.42) | LMNAMAPTNPC1RAB9APOLB | |
| SCHEMBL23638350 | 0.75 | NPC1 (0.37) | LMNAMAPTNPC1RAB9APOLB | |
| Methane SCHEMBL19031863 | 0.75 | SCN4A (0.41) | LMNAMAPTNPC1RAB9APOLB | |
| SCHEMBL27257093 | 0.73 | PRMT6 (0.36) | LMNAMAPTNPC1RAB9APOLB | |
| SCHEMBL28225622 | 0.72 | ALDH1A1 (0.33) | LMNAKDM4EAR | |
| SCHEMBL28684123 | 0.69 | NOS1 (0.53) | MAPTNPC1RAB9APOLBIDH1 | |
| Bicarbonate SCHEMBL5617163 | 0.69 | NPC1 (0.43) | LMNAMAPTNPC1RAB9APOLB | |
| SCHEMBL14671141 | 0.69 | LMNA (0.52) | LMNAMAPTPOLBKDM4EHTT | |
| SCHEMBL950089 | 0.68 | LMNA (0.45) | LMNAMAPTPOLBKDM4EIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104955454-A | Antagonists of chemokine receptors | CHEMOCENTRYX INC | 2015-09-30 | — | — | CN | disclosed |