Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | DHPS | P49366 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490640 | 0.83 | LMNA (0.73) | LMNASIGMAR1CYP1A2ALOX15NFKB1 | |
| SCHEMBL5924357 | 0.82 | SIGMAR1 (0.40) | LMNAPAOXSIGMAR1HRH3PSMD14 | |
| SCHEMBL2486864 | 0.82 | LMNA (0.77) | LMNASIGMAR1CYP1A2ALOX15NFKB1 | |
| Bromide SCHEMBL9291053 | 0.80 | SIGMAR1 (0.39) | LMNAPAOXSIGMAR1HRH3PSMD14 | |
| SCHEMBL8120185 | 0.78 | LMNA (0.70) | LMNAMEN1KMT2ASIGMAR1CYP1A2 | |
| SCHEMBL4392338 | 0.76 | PAOX (0.50) | PAOXSIGMAR1HRH3 | |
| Hydrochloric Acid SCHEMBL3667165 | 0.76 | LMNA (0.75) | LMNAMEN1KMT2ACYP1A2ALOX15 | |
| SCHEMBL17057277 | 0.72 | PAOX (0.42) | PAOXSIGMAR1HRH3 | |
| SCHEMBL6663287 | 0.72 | PAOX (0.60) | PAOXSIGMAR1HRH3 | |
| SCHEMBL20234244 | 0.72 | PAOX (0.60) | PAOXSIGMAR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379506-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | ArQule, Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010078421-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |