Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | DHPS | P49366 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2486864 | 0.98 | LMNA (0.77) | LMNAHRH3SIGMAR1CYP1A2ALOX15 | |
| SCHEMBL8120185 | 0.94 | LMNA (0.70) | LMNAHRH3SIGMAR1CYP1A2ALOX15 | |
| SCHEMBL8000933 | 0.84 | LMNA (1.00) | LMNAHRH3SIGMAR1CYP1A2ALDH1A1 | |
| Guanethidine SCHEMBL34754 | 0.84 | LMNA (1.00) | LMNAHRH3SIGMAR1CYP1A2ALDH1A1 | |
| SCHEMBL2492841 | 0.83 | LMNA (0.52) | LMNAHRH3SIGMAR1CYP1A2ALOX15 | |
| SCHEMBL2905469 | 0.80 | SIGMAR1 (0.51) | LMNAHRH3SIGMAR1 | |
| Iodide SCHEMBL4008478 | 0.79 | SIGMAR1 (0.50) | LMNAHRH3SIGMAR1 | |
| SCHEMBL2905192 | 0.79 | LMNA (0.52) | LMNAHRH3SIGMAR1ALDH1A1TSHR | |
| Sulfuric Acid SCHEMBL11365481 | 0.78 | LMNA (0.78) | LMNAHRH3SIGMAR1ALOX15ALDH1A1 | |
| Iodide SCHEMBL4010790 | 0.77 | LMNA (0.50) | LMNAHRH3SIGMAR1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379506-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | ArQule, Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010078421-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| EP-1056733-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999042458-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 1999-08-26 | — | — | WO | disclosed |