Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490640 | 0.98 | LMNA (0.73) | LMNAHRH3ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL8120185 | 0.92 | LMNA (0.70) | LMNAHRH3SIGMAR1CYP1A2ALOX15 | |
| SCHEMBL8000933 | 0.87 | LMNA (1.00) | LMNAHRH3ALDH1A1TSHRL3MBTL1 | |
| Guanethidine SCHEMBL34754 | 0.87 | LMNA (1.00) | LMNAHRH3ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL2492841 | 0.82 | LMNA (0.52) | LMNAHRH3SIGMAR1CYP1A2ALOX15 | |
| SCHEMBL2905192 | 0.81 | LMNA (0.52) | LMNAHRH3ALDH1A1TSHRL3MBTL1 | |
| Iodide SCHEMBL4010790 | 0.80 | LMNA (0.50) | LMNAHRH3ALDH1A1TSHRL3MBTL1 | |
| Guanethidine SCHEMBL11658850 | 0.79 | LMNA (0.81) | LMNAHRH3ALDH1A1TSHRL3MBTL1 | |
| Sulfuric Acid SCHEMBL11726252 | 0.79 | LMNA (0.81) | LMNAHRH3ALDH1A1TSHRL3MBTL1 | |
| Guanethidine SCHEMBL4332009 | 0.79 | LMNA (0.81) | LMNAHRH3ALDH1A1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379506-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | ArQule, Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010078421-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |