Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 3/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.38 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24933771 | 0.88 | IKBKB (0.42) | PARP1IKBKBCHUKHSD17B1HSD17B2 | |
| SCHEMBL24933191 | 0.86 | MMP3 (0.40) | PARP1HSD17B1HSD17B2PLA2G2APLA2G10 | |
| SCHEMBL24932950 | 0.86 | HSD17B2 (0.52) | PARP1IKBKBCHUKHSD17B1HSD17B2 | |
| SCHEMBL24933186 | 0.84 | HSD17B1 (0.44) | PARP1HSD17B1HSD17B2SCN9A | |
| SCHEMBL24932959 | 0.84 | HSD17B1 (0.44) | PARP1IKBKBHSD17B1HSD17B2SCN9A | |
| SCHEMBL24933754 | 0.83 | HSD17B2 (0.53) | HSD17B1HSD17B2 | |
| SCHEMBL30896148 | 0.83 | HSD17B2 (0.53) | HSD17B1HSD17B2 | |
| SCHEMBL24933348 | 0.80 | CDC7 (0.47) | PARP1IKBKBCHUKHSD17B1HSD17B2 | |
| SCHEMBL24933605 | 0.80 | HSD17B2 (0.41) | PARP1HSD17B1HSD17B2 | |
| SCHEMBL24933312 | 0.80 | BTK (0.42) | IKBKBCHUKHSD17B1HSD17B2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373809-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | Novartis AG (CH) | 2024-05-29 | — | — | EP | claimed |
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | claimed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | claimed |
| EP-4373809-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | Novartis AG (CH) | 2024-05-29 | — | — | EP | disclosed |
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |