Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | USP7 | Q93009 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24933350 | 0.88 | RXRA (0.37) | HSD17B1HSD17B2MAPK8CDC7 | |
| SCHEMBL24933185 | 0.86 | PARP1 (0.46) | HSD17B1HSD17B2PLA2G10PLA2G2ASCN9A | |
| SCHEMBL24933348 | 0.83 | CDC7 (0.47) | HSD17B1HSD17B2MAPK8PARP1CDC7 | |
| SCHEMBL24933186 | 0.80 | HSD17B1 (0.44) | HSD17B1HSD17B2BRD4SCN9APARP1 | |
| SCHEMBL24932959 | 0.80 | HSD17B1 (0.44) | HSD17B1HSD17B2SCN9APARP1 | |
| SCHEMBL24932950 | 0.80 | HSD17B2 (0.52) | HSD17B1HSD17B2CDK2BRD4SCN9A | |
| SCHEMBL30896148 | 0.79 | HSD17B2 (0.53) | HSD17B1HSD17B2BRD4CDC7 | |
| SCHEMBL24933754 | 0.79 | HSD17B2 (0.53) | HSD17B1HSD17B2BRD4CDC7 | |
| SCHEMBL24933175 | 0.77 | HSD17B1 (0.42) | HSD17B1HSD17B2SCN9APARP1 | |
| SCHEMBL24933771 | 0.77 | IKBKB (0.42) | HSD17B1HSD17B2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | claimed |
| EP-4373809-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | Novartis AG (CH) | 2024-05-29 | — | — | EP | disclosed |
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |